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Zwitterionic Manganese and Gadolinium Metal–Organic Frameworks as Efficient Contrast Agents for in Vivo Magnetic Resonance Imaging
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2017-11-16 00:00:00 , DOI: 10.1021/acsami.7b09608 Liang Qin 1, 2 , Zi-Yan Sun 3, 4 , Kai Cheng 4 , Shu-Wen Liu 1 , Jian-Xin Pang 1 , Li-Ming Xia 3 , Wen-Hua Chen 1 , Zhen Cheng 4 , Jin-Xiang Chen 1
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2017-11-16 00:00:00 , DOI: 10.1021/acsami.7b09608 Liang Qin 1, 2 , Zi-Yan Sun 3, 4 , Kai Cheng 4 , Shu-Wen Liu 1 , Jian-Xin Pang 1 , Li-Ming Xia 3 , Wen-Hua Chen 1 , Zhen Cheng 4 , Jin-Xiang Chen 1
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Two water-stable three-dimensional Mn- and Gd-based metal–organic frameworks (MOFs), {[Mn2(Cmdcp)2(H2O)2]·H2O}n (1) and {[Gd(Cmdcp)(H2O)3](NO3)·3H2O}n (2, H3CmdcpBr = N-(4-carboxy benzyl)-(3,5-dicarboxyl)pyridinium bromide), have been prepared and analyzed. In vitro magnetic resonance imaging indicated that MOFs 1 and 2 possess relaxivity r1 values of 17.50 and 13.46 mM–1·S–1, respectively, which are superior to that of the control Gd-DTPA (r1 = 4.87 mM–1·S–1, DTPA = diethylene triamine pentaacetate). MOFs 1 and 2 also possessed good biocompatibility and low cytotoxicity against a model cell line. In vivo magnetic resonance images of treated Kunming mice indicated that kidneys showed remarkably positive signal enhancement after 15 min with intravenous administration of MOF 1 and the hyperintensity of both kidneys persisted for about 240 min with no obvious tissue damage. MOF 1 is therefore promising in vivo probes for imaging intravascular diseases and renal dysfunction.
中文翻译：
两性离子锰和d金属有机骨架作为体内磁共振成像的高效造影剂
两种水稳定的基于Mn和Gd的三维金属有机骨架（MOF），{[Mn 2（Cmdcp）2（H 2 O）2 ]·H 2 O} n（1）和{[Gd（ Cmdcp）（H 2 O）3 ]（NO 3）·3H 2 O} n（2，H 3 CmdcpBr = N-（4-羧基苄基）-（3,5-二羧基）溴化吡啶鎓），并制备分析。体外磁共振成像表明，MOF 1和MOF 2的弛豫度r 1分别为17.50和13.46 mM–1 ·S –1分别优于对照Gd-DTPA（r 1 = 4.87 mM –1 ·S –1，DTPA =五乙酸二亚乙基三胺）。MOF 1和2对模型细胞系也具有良好的生物相容性和低细胞毒性。经治疗的昆明小鼠的体内磁共振图像表明，静脉内注射MOF 1后，肾脏在15分钟后显示出明显的阳性信号增强，并且两个肾脏的高强度持续约240分钟，而没有明显的组织损伤。因此，MOF 1有望用于成像血管内疾病和肾功能不全的体内探针。
更新日期：2017-11-16
中文翻译：
两性离子锰和d金属有机骨架作为体内磁共振成像的高效造影剂
两种水稳定的基于Mn和Gd的三维金属有机骨架（MOF），{[Mn 2（Cmdcp）2（H 2 O）2 ]·H 2 O} n（1）和{[Gd（ Cmdcp）（H 2 O）3 ]（NO 3）·3H 2 O} n（2，H 3 CmdcpBr = N-（4-羧基苄基）-（3,5-二羧基）溴化吡啶鎓），并制备分析。体外磁共振成像表明，MOF 1和MOF 2的弛豫度r 1分别为17.50和13.46 mM–1 ·S –1分别优于对照Gd-DTPA（r 1 = 4.87 mM –1 ·S –1，DTPA =五乙酸二亚乙基三胺）。MOF 1和2对模型细胞系也具有良好的生物相容性和低细胞毒性。经治疗的昆明小鼠的体内磁共振图像表明，静脉内注射MOF 1后，肾脏在15分钟后显示出明显的阳性信号增强，并且两个肾脏的高强度持续约240分钟，而没有明显的组织损伤。因此，MOF 1有望用于成像血管内疾病和肾功能不全的体内探针。
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