Zirconium-Based Nanoscale Metal–Organic Framework/Poly(ε-caprolactone) Mixed-Matrix Membranes as Effective Antimicrobials,ACS Applied Materials & Interfaces

当前位置： X-MOL 学术 › ACS Appl. Mater. Interfaces › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Zirconium-Based Nanoscale Metal–Organic Framework/Poly(ε-caprolactone) Mixed-Matrix Membranes as Effective Antimicrobials
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2017-11-16 00:00:00 , DOI: 10.1021/acsami.7b15826
Ming Liu _{1,

2} , Lei Wang ₁ , Xiaohua Zheng _{1,

2} , Zhigang Xie ₁

Affiliation

Metal–organic framework (MOF)–polymer mixed-matrix membranes (MMMs) have shown their superior performance in gas separation. However, their biological application has not been well-explored yet. Herein, a series of zirconium-based MOF MMMs with high MOF loading and homogeneous composition have been prepared through a facile drawdown coating process. Poly(ε-caprolactone) (PCL) has been selected as a binder for its good biocompatibility and biodegradability. Zr-MOF nanoparticles, UiO-66, and MOF-525, have been utilized as “filler” because of their superior chemical stability, good biological safety, and versatile functions. Both UiO-66/PCL MMMs and MOF-525/PCL MMMs have a uniform appearance even at the highest loading of 50 wt % for UiO-66 and 30 wt % for MOF-525, respectively. The integrity of pore structures of UiO-66 within MMMs maintains well, which is evidenced by dye separation. All obtained MMMs possess good biocompatibility and mechanical property. Upon irradiation, MOF-525/PCL MMMs generate reactive oxygen species and serve as effective antibacterial photodynamic agents against Escherichia coli. This study offers an alternative system for forming homogeneous MOF/polymer MMMs and represents the first example of exploiting hybrid MMMs for biological applications.

中文翻译：

锆基纳米级金属-有机骨架/聚（ε-己内酯）混合基质膜作为有效的抗菌剂

金属-有机骨架（MOF）-聚合物混合基质膜（MMM）在气体分离中表现出卓越的性能。但是，它们的生物学应用尚未得到很好的探索。在此，已经通过简便的压延涂覆工艺制备了具有高MOF负载和均质组成的一系列锆基MOF MMM。聚（ε-己内酯）（PCL）因其良好的生物相容性和生物降解性而被选作粘合剂。Zr-MOF纳米颗粒UiO-66和MOF-525由于其优异的化学稳定性，良好的生物安全性和多功能性，已被用作“填充剂”。UiO-66 / PCL MMM和MOF-525 / PCL MMM均具有均匀的外观，即使分别在UiO-66的最高负载为50 wt％和MOF-525的最高负载为30 wt％的情况下也是如此。MMM中UiO-66的孔结构完整性保持良好，染料分离证明了这一点。所有获得的MMM都具有良好的生物相容性和机械性能。辐照后，MOF-525 / PCL MMM会产生活性氧，并作为有效的抗菌光动力剂来抵抗大肠杆菌。这项研究提供了形成均质MOF /聚合物MMM的替代系统，并代表了将杂化MMM用于生物学应用的第一个示例。

更新日期：2017-11-17

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11