Enantioselective Palladium-Catalyzed Intramolecular α-Arylative Desymmetrization of 1,3-Diketones,Journal of the American Chemical Society

当前位置： X-MOL 学术 › J. Am. Chem. Soc. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Enantioselective Palladium-Catalyzed Intramolecular α-Arylative Desymmetrization of 1,3-Diketones
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2017-11-14 00:00:00 , DOI: 10.1021/jacs.7b10365
Chendan Zhu ₁ , Dingyi Wang ₁ , Yue Zhao ₁ , Wei-Yin Sun ₁ , Zhuangzhi Shi ₁

Affiliation

An efficient enantioselective protocol has been reported to build highly oxygenated and densely substituted bicyclo[m.n.1] skeletons through intramolecular asymmetric α-arylative desymmetrization of 1,3-diketones. Employing Pd catalyst and FOXAP ligand, various bicyclo[m.n.1] skeleton with different size can be accessed with high enantio- and diastereoselectivities. Utilizing the present method as a key step, formal asymmetric total synthesis of the (−)-parvifoline has been demonstrated.

中文翻译：

1,3-二酮的对映选择性钯催化的分子内α-芳基不对称化

据报道，一种有效的对映选择性方案可构建高度氧化和密集取代的双环[ m]。Ñ 0.1]到的1,3-二酮的分子内不对称α-arylative desymmetrization骨架。使用Pd催化剂和FOXAP配体，各种双环[ m。[ 0.1] [n.1]骨架可以通过高对映选择性和非对映选择性获得。利用本发明的方法作为关键步骤，已经证明了（-）-细小佛碱的形式不对称全合成。

更新日期：2017-11-16

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11