Advanced smart-photosensitizers for more effective cancer treatment,Biomaterials Science

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Advanced smart-photosensitizers for more effective cancer treatment
Biomaterials Science ( IF 5.8 ) Pub Date : 2017-11-01 00:00:00 , DOI: 10.1039/c7bm00872d
Wooram Park _{1,

2,

3,

4,

5} , Soojeong Cho _{1,

2,

3,

4,

5} , Jieun Han _{6,

7,

8,

9,

10} , Heejun Shin _{6,

7,

8,

9,

10} , Kun Na _{6,

7,

8,

9,

10} , Byeongdu Lee _{5,

11,

12,

13} , Dong-Hyun Kim _{1,

2,

3,

4,

5}

Affiliation

Photodynamic therapy (PDT) based upon the use of light and photosensitizers (PSs) has been used as a novel treatment approach for a variety of tumors. It, however, has several major limitations in the clinic: poor water solubility, long-term phototoxicity, low tumor targeting efficacy, and limited light penetration. With advances in nanotechnology, materials science, and clinical interventional imaging procedures, various smart-PSs have been developed for improving their cancer-therapeutic efficacy while reducing the adverse effects. Here, we briefly review state-of-the-art smart-PSs and discuss the future directions of PDT technology.

中文翻译：

先进的智能光敏剂，可更有效地治疗癌症

基于光和光敏剂（PSs）的光动力疗法（PDT）已被用作针对多种肿瘤的新型治疗方法。但是，它在临床上有几个主要局限性：水溶性差，长期光毒性，靶向肿瘤的功效低以及光穿透性有限。随着纳米技术，材料科学和临床介入成像程序的发展，已经开发了各种智能PS，以改善其癌症治疗效果并减少不良影响。在这里，我们简要回顾了最新的智能PS，并讨论了PDT技术的未来发展方向。

更新日期：2017-11-16

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