DIANA-TarBase v8 (http://www.microrna.gr/tarbase) is a reference database devoted to the indexing of experimentally supported microRNA (miRNA) targets. Its eighth version is the first database indexing >1 million entries, corresponding to ∼670 000 unique miRNA-target pairs. The interactions are supported by >33 experimental methodologies, applied to ∼600 cell types/tissues under ∼451 experimental conditions. It integrates information on cell-type specific miRNA–gene regulation, while hundreds of thousands of miRNA-binding locations are reported. TarBase is coming of age, with more than a decade of continuous support in the non-coding RNA field. A new module has been implemented that enables the browsing of interactions through different filtering combinations. It permits easy retrieval of positive and negative miRNA targets per species, methodology, cell type and tissue. An incorporated ranking system is utilized for the display of interactions based on the robustness of their supporting methodologies. Statistics, pie-charts and interactive bar-plots depicting the database content are available through a dedicated result page. An intuitive interface is introduced, providing a user-friendly application with flexible options to different queries.

中文翻译：

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DIANA-TarBase v8：经过十年的实验支持的miRNA与基因相互作用的集合

DIANA-TarBase v8（http://www.microrna.gr/tarbase）是一个参考数据库，专门用于索引实验支持的microRNA（miRNA）靶标。它的第八个版本是第一个索引> 1百万个条目的数据库，对应约67万个独特的miRNA-靶标对。相互作用得到了> 33种实验方法的支持，并在约451种实验条件下应用于约600种细胞类型/组织。它整合了有关细胞类型特异性miRNA基因调控的信息，而据报道有成千上万的miRNA结合位置。TarBase已经成熟，在非编码RNA领域拥有十多年的持续支持。已实现一个新模块，该模块允许通过不同的过滤组合来浏览交互。它允许按物种，方法学，细胞类型和组织轻松检索阳性和阴性miRNA靶标。基于其支持方法的鲁棒性，将合并的排名系统用于交互的显示。可以通过专用结果页面获得描述数据库内容的统计信息，饼图和交互式条形图。引入了直观的界面，为用户友好的应用程序提供了针对不同查询的灵活选项。