A selective nanosensor for ultrafast detection of Cu2+ ions based on C5 DNA-templated gold nanoclusters and Fenton-like reaction,Analytical Methods

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A selective nanosensor for ultrafast detection of Cu2+ ions based on C5 DNA-templated gold nanoclusters and Fenton-like reaction
Analytical Methods ( IF 2.7 ) Pub Date : 2017-10-12 00:00:00 , DOI: 10.1039/c7ay02247f
Taiping Qing _{1,

2,

3,

4,

5} , Hongchang Bu _{1,

2,

3,

4,

5} , Xiaoxiao He _{1,

2,

3,

4,

5} , Dinggeng He _{1,

2,

3,

4,

5} , Bing Zhou _{1,

2,

3,

4,

5} , Huanhuan Sun _{1,

2,

3,

4,

5} , Ruichen Jia _{1,

2,

3,

4,

5} , Wenjie Ma _{1,

2,

3,

4,

5} , Kemin Wang _{1,

2,

3,

4,

5}

Affiliation

Copper pollution has become a very serious problem in modern society with the increasing industrial emission and the acid mine drainage. Copper deficiency or excess copper accumulation in human and animal livers can bring both oxidative stress and severe disorders. Thus, the development of a simple and efficient strategy for Cu²⁺ ion detection in water and blood samples is very necessary and meaningful. In this study, a simple, fast, and sensitive fluorescence method was put forward to detect Cu²⁺ ions based on C5 DNA-templated gold nanoclusters (AuNCs) and Fenton-like reactions. Under aerobic conditions, ascorbic acid is not only involved in the reduction of Cu²⁺, but also reacts with O₂ to produce H₂O₂. Then, hydroxyl radical (˙OH), yielded by H₂O₂ and Cu⁺, can seriously quench the fluorescence of AuNCs. Attributed to the unique Fenton-like reaction between ascorbic acid and the Cu²⁺ ions, high selectivity was achieved for Cu²⁺ ion monitoring using this nanosensor, and the practical applications of this nanosensor in real water and blood samples were realized.

中文翻译：

基于C5 DNA模板金纳米团簇和类Fenton反应的超快检测Cu ²⁺离子的选择性纳米传感器

随着工业排放量的增加和酸性矿山排水的增加，铜污染已成为现代社会的一个非常严重的问题。人和动物肝脏中的铜缺乏或过多的铜积累会带来氧化应激和严重的疾病。因此，开发一种简单有效的水和血液样品中Cu ²⁺离子检测策略非常必要且有意义。在这项研究中，提出了一种基于C5 DNA模板金纳米簇（AuNCs）和Fenton样反应的简单，快速，灵敏的荧光方法来检测Cu ²⁺离子。在有氧条件下，抗坏血酸不仅参与在Cu的还原²⁺，也被O反应₂生成H ₂ ö₂。然后，由H₂ O₂和Cu⁺产生的羟基自由基（˙OH）可以严重淬灭AuNCs的荧光。归因于抗坏血酸和Cu²⁺离子之间独特的Fenton样反应，使用该纳米传感器实现了对Cu²⁺离子监测的高选择性，并实现了该纳米传感器在实际水和血液样本中的实际应用。

更新日期：2017-11-16

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