Cancer nanomedicine: from PDGF targeted drug delivery,RSC Medicinal Chemistry

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Cancer nanomedicine: from PDGF targeted drug delivery
RSC Medicinal Chemistry ( IF 4.1 ) Pub Date : 2017-09-28 00:00:00 , DOI: 10.1039/c7md00391a
Chandrababu Rejeeth _{1,

2,

3,

4,

5} , Raju Vivek _{1,

2,

3,

4,

5} , Varukattu NipunBabu _{6,

7,

8,

9,

10} , Alok Sharma _{1,

2,

3,

4,

5} , Xianting Ding _{1,

2,

3,

4,

5} , Kun Qian _{1,

2,

3,

4,

5}

Affiliation

An innovative approach for the distinctively efficient action of smart targeted drug delivery to a specific cell type is obtained through the modification of the surface of nanoparticles. Specifically, the work identifies a cell surface receptor targeting drug delivery nanosystem based on mesoporous silica loaded with the anticancer drug cisplatin (cis-DDP) and poly-acrylic acid (PAA). A specific target is the PDGF receptors expressed in cervical cancer cells, thus making the PAA functionalized nanocomposite a suitable and promising nano-medicine for the targeting of PDGF-overexpressing cancers in the near future.

中文翻译：

癌症纳米药物：来自PDGF的靶向药物递送

通过修饰纳米粒子的表面，获得了一种创新的方法，可以有效地将智能靶向药物输送到特定细胞类型，从而具有独特的高效作用。具体来说，这项工作确定了基于介孔二氧化硅的细胞表面受体靶向药物输送纳米系统，该介孔二氧化硅载有抗癌药物顺铂（cis -DDP）和聚丙烯酸（PAA）。具体的靶标是在宫颈癌细胞中表达的PDGF受体，因此使PAA功能化的纳米复合材料成为在不久的将来靶向过表达PDGF的癌症的合适且有前途的纳米药物。

更新日期：2017-11-16

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