Synthesis, characterization, and anticancer activity of two mixed ligand copper(II) complexes by regulating the VEGF/VEGFR2 signaling pathway,Dalton Transactions

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Synthesis, characterization, and anticancer activity of two mixed ligand copper(II) complexes by regulating the VEGF/VEGFR2 signaling pathway
Dalton Transactions ( IF 3.5 ) Pub Date : 2017-11-02 00:00:00 , DOI: 10.1039/c7dt03242k
Xiu-Ying Qin _{1,

2,

3,

4,

5} , Ya-Nan Wang _{1,

2,

3,

4} , Xin-Ping Yang _{1,

2,

3,

4} , Juan-Juan Liang _{1,

2,

3,

4} , Ji-Lin Liu _{1,

2,

3,

4} , Zhao-Hui Luo _{1,

2,

3,

4}

Affiliation

The single crystals of two novel mixed-ligand copper(II)-based complexes were obtained and characterized. These complexes can remarkably induce apoptosis, inhibit proliferation, suppress migration and metastasis, and inhibit angiogenesis to inhibit the growth of cervical cancer by down-regulating the expressions of the important proteins FAK, Akt and Erk1/2 or their phosphorylated proteins p-FAK, p-Akt, and p-Erk1/2 downstream of the VEGF/VEGFR2 signaling pathway.

中文翻译：

通过调节VEGF / VEGFR2信号通路的两种混合配体铜（II）配合物的合成，表征和抗癌活性

获得并表征了两种新型的基于混合配体铜（II）的配合物的单晶。这些复合物可通过下调重要蛋白FAK，Akt和Erk1 / 2或其磷酸化蛋白p-FAK的表达来显着诱导凋亡，抑制增殖，抑制迁移和转移并抑制血管生成以抑制子宫颈癌的生长， VEGF / VEGFR2信号通路下游的p-Akt和p-Erk1 / 2。

更新日期：2017-11-16

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