Organocatalytic Asymmetric Synthesis of Six-Membered Carbocycle-Based Spiro Compounds,Advanced Synthesis & Catalysis

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Organocatalytic Asymmetric Synthesis of Six-Membered Carbocycle-Based Spiro Compounds
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2017-11-16 09:21:45 , DOI: 10.1002/adsc.201700927
Xin Xie ₁ , Wei Huang ₂ , Cheng Peng _{1,

2} , Bo Han ₁

Affiliation

Well-developed asymmetric organocatalysis has been widely incorporated in various cascade/tandem sequences, providing a simple access to structurally complex target molecules in a highly stereoselective fashion, including spirocyclic compounds. Among all types of spirocyclic skeletons, those containing a six-membered carbocyclic ring are recognized as an important core framework with up to six consecutive stereogenic centers and this motif is commonly found in many natural products, biologically active molecules and lead compounds. This review describes the asymmetric synthesis of spirocyclic compounds containing six-membered carbocycles using small organic molecules as catalysts.

中文翻译：

六元碳环螺化合物的有机催化不对称合成

发达的不对称有机催化已广泛并入各种级联/串联序列中，以高度立体选择性的方式（包括螺环化合物）轻松访问结构复杂的目标分子。在所有类型的螺环骨架中，含有六元碳环的骨架被认为是重要的核心构架，具有多达六个连续的立体生成中心，并且该基序通常出现在许多天然产物，生物活性分子和先导化合物中。这篇综述描述了使用小有机分子作为催化剂不对称合成包含六元碳环的螺环化合物的方法。

更新日期：2017-11-16

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