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Regeneration of the entire human epidermis using transgenic stem cells
Nature ( IF 50.5 ) Pub Date : 2017-11-08 00:00:00 , DOI: 10.1038/nature24487 Tobias Hirsch , Tobias Rothoeft , Norbert Teig , Johann W. Bauer , Graziella Pellegrini , Laura De Rosa , Davide Scaglione , Julia Reichelt , Alfred Klausegger , Daniela Kneisz , Oriana Romano , Alessia Secone Seconetti , Roberta Contin , Elena Enzo , Irena Jurman , Sonia Carulli , Frank Jacobsen , Thomas Luecke , Marcus Lehnhardt , Meike Fischer , Maximilian Kueckelhaus , Daniela Quaglino , Michele Morgante , Silvio Bicciato , Sergio Bondanza , Michele De Luca
Nature ( IF 50.5 ) Pub Date : 2017-11-08 00:00:00 , DOI: 10.1038/nature24487 Tobias Hirsch , Tobias Rothoeft , Norbert Teig , Johann W. Bauer , Graziella Pellegrini , Laura De Rosa , Davide Scaglione , Julia Reichelt , Alfred Klausegger , Daniela Kneisz , Oriana Romano , Alessia Secone Seconetti , Roberta Contin , Elena Enzo , Irena Jurman , Sonia Carulli , Frank Jacobsen , Thomas Luecke , Marcus Lehnhardt , Meike Fischer , Maximilian Kueckelhaus , Daniela Quaglino , Michele Morgante , Silvio Bicciato , Sergio Bondanza , Michele De Luca
Junctional epidermolysis bullosa (JEB) is a severe and often lethal genetic disease caused by mutations in genes encoding the basement membrane component laminin-332. Surviving patients with JEB develop chronic wounds to the skin and mucosa, which impair their quality of life and lead to skin
中文翻译：
使用转基因干细胞再生整个人类表皮
大结节性表皮松解症（JEB）是一种严重的且常致死性的遗传病，由编码基底膜成分层粘连蛋白332的基因突变引起。幸存的JEB患者出现皮肤和粘膜慢性伤口，损害其生活质量并导致皮肤
更新日期：2017-11-16
中文翻译：
使用转基因干细胞再生整个人类表皮
大结节性表皮松解症（JEB）是一种严重的且常致死性的遗传病，由编码基底膜成分层粘连蛋白332的基因突变引起。幸存的JEB患者出现皮肤和粘膜慢性伤口，损害其生活质量并导致皮肤
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