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Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity
Nature ( IF 50.5 ) Pub Date : 2017-11-08 00:00:00 , DOI: 10.1038/nature24302 Shabnam Shalapour , Xue-Jia Lin , Ingmar N. Bastian , John Brain , Alastair D. Burt , Alexander A. Aksenov , Alison F. Vrbanac , Weihua Li , Andres Perkins , Takaji Matsutani , Zhenyu Zhong , Debanjan Dhar , Jose A. Navas-Molina , Jun Xu , Rohit Loomba , Michael Downes , Ruth T. Yu , Ronald M. Evans , Pieter C. Dorrestein , Rob Knight , Christopher Benner , Quentin M. Anstee , Michael Karin
Nature ( IF 50.5 ) Pub Date : 2017-11-08 00:00:00 , DOI: 10.1038/nature24302 Shabnam Shalapour , Xue-Jia Lin , Ingmar N. Bastian , John Brain , Alastair D. Burt , Alexander A. Aksenov , Alison F. Vrbanac , Weihua Li , Andres Perkins , Takaji Matsutani , Zhenyu Zhong , Debanjan Dhar , Jose A. Navas-Molina , Jun Xu , Rohit Loomba , Michael Downes , Ruth T. Yu , Ronald M. Evans , Pieter C. Dorrestein , Rob Knight , Christopher Benner , Quentin M. Anstee , Michael Karin
The role of adaptive immunity in early cancer development is controversial. Here we show that chronic inflammation and fibrosis in humans and mice with non-alcoholic fatty liver disease is accompanied by accumulation of liver-resident immunoglobulin-A-producing (IgA+) cells. These cells also express programmed death
中文翻译：
炎症诱导的IgA +细胞破坏了抗肝癌免疫力
适应性免疫在早期癌症发展中的作用是有争议的。在这里，我们显示人类和非酒精性脂肪肝疾病的小鼠的慢性炎症和纤维化伴随着肝脏驻留性免疫球蛋白A产生（IgA +）细胞的积累。这些细胞也表达程序性死亡
更新日期：2017-11-16
中文翻译：
炎症诱导的IgA +细胞破坏了抗肝癌免疫力
适应性免疫在早期癌症发展中的作用是有争议的。在这里，我们显示人类和非酒精性脂肪肝疾病的小鼠的慢性炎症和纤维化伴随着肝脏驻留性免疫球蛋白A产生（IgA +）细胞的积累。这些细胞也表达程序性死亡
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