Double Catalytic Kinetic Resolution (DoCKR) of Acyclic anti-1,3-Diols: The Additive Horeau Amplification,Angewandte Chemie International Edition

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Double Catalytic Kinetic Resolution (DoCKR) of Acyclic anti-1,3-Diols: The Additive Horeau Amplification
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2017-11-15 12:01:08 , DOI: 10.1002/anie.201709844
Jérémy Merad ₁ , Prashant Borkar ₁ , Frédéric Caijo ₂ , Jean-Marc Pons ₁ , Jean-Luc Parrain ₁ , Olivier Chuzel ₁ , Cyril Bressy ₁

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Give a second chance to your catalyst! The concept of a synergistic double catalytic kinetic resolution (DoCKR) was successfully applied to racemic acyclic anti-1,3-diols, a common motif in natural products. The organocatalyzed double acylation led to diesters and recovered diols having high enantiopurities. It was first developed with C₂-symmetrical diols and then further extended to non-C₂-symmetrical anti diols to prepare useful chiral building blocks.

中文翻译：

无环抗1，3-二元醇的双催化动力学拆分（DoCKR）：加性荷罗扩增

给您的催化剂第二次机会！协同双催化动力学拆分（DoCKR）的概念已成功应用于外消旋无环抗-1,3-二醇（天然产物中的常见基序）。有机催化的双酰化反应产生了具有高对映体纯度的二酯和回收的二醇。它首先用C _2-对称二醇开发，然后进一步扩展到非C _2-对称抗二醇，以制备有用的手性结构单元。

更新日期：2017-11-16

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