4-Substituted thieno[2,3-d]pyrimidines were designed, synthesized and evaluated for antibacterial activity. Docking studies suggest the bacterial dihydropteroate synthase inhibitory activity of potent compounds. Hence, its binding affinity with DHPS enzyme was also determined.

中文翻译：

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4-取代的噻吩并[2,3-d]嘧啶类作为有效的抗菌剂：合理的设计，微波辅助合成，生物学评估和分子对接研究

设计，合成4-取代的噻吩并[2,3- d ]嘧啶并评估其抗菌活性。对接研究表明，强效化合物对细菌二氢蝶呤合酶具有抑制活性。因此，还确定了其与DHPS酶的结合亲和力。