In this issue of the Journal, Gabriela Adreiotti and colleagues report the results of an updated analysis of glyphosate exposure and cancer risk in the Agricultural Health Study (AHS) (1). The AHS, a prospective cohort study of 57 310 licensed pesticide applicators and 32 347 spouses in Iowa and North Carolina, was initiated in the early 1990s, in large part to address possible causes for the higher incidence of lymphohematopoietic and certain other cancers in farmers compared with the general population (2). From an epidemiologic perspective, designing a study to investigate cancer risk factors associated with farming is challenging because of the difficulty in establishing and recruiting a well-defined population, the large number of farming-related exposures that may be associated with cancer, and the need to create and validate quantitative exposure metrics. The AHS study met these challenges by defining and recruiting the study population from applicants for a restricted-use pesticide license in two states, collecting detailed information on the frequency and duration of use of 50 common pesticides, as well as other farming-related and general population exposures, and estimating lifetime days and intensity-weighted lifetime days of exposure for specific pesticides (2). Intensity of exposure was estimated using an algorithm that accounted for reported use of personal protective equipment, method of application, and whether the applicator personally mixed the pesticides (3). Additional studies were done to validate and refine the pesticide exposure intensity metrics, and exposure information was updated in 1999–2005 by computer-aided telephone interviewing (3,4). A method for multiple imputation was developed to assign pesticide use for nonresponders to the follow-up questionnaire (5).

中文翻译：

---

农业健康研究中的草甘膦使用和癌症发病率：流行病学视角


在本期杂志中，Gabriela Adreiotti 及其同事报告了农业健康研究 (AHS) 中草甘膦暴露和癌症风险的最新分析结果 (1)。 AHS 是一项前瞻性队列研究，对爱荷华州和北卡罗来纳州的 57 310 名持证农药施用者和 32 347 名配偶进行了研究，于 20 世纪 90 年代初启动，主要是为了解决农民中淋巴造血和某些其他癌症发病率较高的可能原因。与一般人群（2）。从流行病学的角度来看，设计一项研究来调查与农业相关的癌症风险因素具有挑战性，因为难以建立和招募明确的人群、大量可能与癌症相关的农业相关暴露以及需要创建和验证定量暴露指标。 AHS 研究通过从两个州的限制使用农药许可证申请人中定义和招募研究人群，收集有关 50 种常见农药的使用频率和持续时间以及其他农业相关和一般农药的详细信息，应对了这些挑战。人口暴露，并估计特定农药的生命周期天数和强度加权生命周期天数 (2)。使用一种算法来估计暴露强度，该算法考虑了报告的个人防护设备的使用情况、施用方法以及施药者是否亲自混合农药 (3)。还进行了其他研究来验证和完善农药暴露强度指标，并通过计算机辅助电话访谈在 1999 年至 2005 年更新了暴露信息 (3,4)。 开发了一种多重插补方法，将无反应者的农药使用情况分配给后续调查问卷 (5)。