Burgeoning epidemiological, animal, and cellular data link environmental endocrine-disrupting chemicals (EDCs) to metabolic dysfunction. Disproportionate exposure to diabetes-associated EDCs may be an underappreciated contributor to disparities in metabolic disease risk. The burden of diabetes is not uniformly borne by American society; rather, this disease disproportionately affects certain populations, including African Americans, Latinos, and low-income individuals. The purpose of this study was to review the evidence linking unequal exposures to EDCs with racial, ethnic, and socioeconomic diabetes disparities in the U.S.; discuss social forces promoting these disparities; and explore potential interventions. Articles examining the links between chemical exposures and metabolic disease were extracted from the U.S. National Library of Medicine for the period of 1966 to 3 December 2016. EDCs associated with diabetes in the literature were then searched for evidence of racial, ethnic, and socioeconomic exposure disparities. Among Latinos, African Americans, and low-income individuals, numerous studies have reported significantly higher exposures to diabetogenic EDCs, including polychlorinated biphenyls, organochlorine pesticides, multiple chemical constituents of air pollution, bisphenol A, and phthalates. This review reveals that unequal exposure to EDCs may be a novel contributor to diabetes disparities. Efforts to reduce the individual and societal burden of diabetes should include educating clinicians on environmental exposures that may increase disease risk, strategies to reduce those exposures, and social policies to address environmental inequality as a novel source of diabetes disparities.

新兴的流行病学，动物和细胞数据将破坏环境内分泌的化学物质（EDC）与代谢功能障碍联系在一起。过度暴露于糖尿病相关的EDC可能是导致代谢疾病风险不均的原因。糖尿病的负担并没有由美国社会统一承担；相反，这种疾病对某些人群的影响尤其严重，其中包括非裔美国人，拉丁裔和低收入人群。这项研究的目的是审查证据表明，在美国，EDC暴露不平等与种族，族裔和社会经济方面的糖尿病差异有关。讨论促进这些差距的社会力量；并探讨潜在的干预措施。文章检查了化学暴露与代谢性疾病之间的联系，摘自美国 国家医学图书馆1966年至2016年12月3日。然后在文献中搜索与糖尿病相关的EDC，以查找种族，族裔和社会经济风险差异的证据。在拉丁美洲人，非裔美国人和低收入人群中，许多研究报告显示，糖尿病致死性EDC的暴露量显着增加，包括多氯联苯，有机氯农药，空气污染的多种化学成分，双酚A和邻苯二甲酸盐。这项审查表明，对EDC的不平等暴露可能是造成糖尿病差异的新原因。减轻糖尿病对个人和社会负担的工作应包括对临床医生进行有关可能增加疾病风险的环境暴露的教育，减少这些疾病暴露的策略，