In recent years, phthalocyanines (Pcs) have been widely used as photosensitizer in photodynamic therapy applications. Because of their strong absorptions in the near‐infrared region (640–700 nm). The integration of phthalocyanine derivatives to a nanoparticle is expected to be efficient way to improve the activity of the photosensitizer on the targeted tissue. It is known that the integrated molecules not only show better accumulation on tumor tissue but also reduce toxicity in healthy tissues. In this study, the ZnPc molecule was synthesized and integrated to the TiO₂ nanoparticle, to investigate the potential of PDT and its cytotoxicity. Additionally, ZnPc and ZnPc‐TiO₂ molecules were labeled with ¹³¹I and it was aimed to put forth the nuclear imaging/therapy potentials of ¹³¹I labeled ZnPc/ZnPc‐TiO₂ by determining in vitro uptakes in mouse mammary carcinoma (EMT6), human cervical adenocarcinoma (HeLa). In result of our study, it was observed that the radiolabeling yields of the synthesized ZnPc and ZnPc‐TiO₂ with ¹³¹I were quite high. In vitro uptake studies shown that ¹³¹I‐ZnPc‐TiO₂ could be a potential agent for nuclear imaging/treatment of breast and cervical cancers. According to PDT results, ZnPc‐TiO₂ might have as to be a potential PDT agent in the treatment of cervical tumor. ZnPc and ZnPc‐TiO₂ might be used as theranostic agents.

中文翻译：

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酞菁锌结合的TiO2纳米粒子在乳腺癌和宫颈癌中的光动力学治疗和核成像活性

近年来，酞菁（Pcs）已被广泛用作光动力治疗应用中的光敏剂。由于它们在近红外区域（640-700 nm）具有很强的吸收能力。酞菁衍生物与纳米颗粒的整合被认为是提高光敏剂在靶组织上的活性的有效方法。众所周知，整合分子不仅在肿瘤组织上显示出更好的积累，而且还降低了健康组织的毒性。在这项研究中，ZnPc分子被合成并整合到TiO ₂纳米颗粒中，以研究PDT的潜力及其细胞毒性。此外，ZnPc和ZnPc-TiO ₂分子用¹³¹标记I和它的目的是通过确定小鼠乳腺癌（EMT6），人宫颈腺癌（HeLa）的体外摄取量，提出¹³¹ I标记的ZnPc / ZnPc-TiO ₂的核成像/治疗潜力。我们的研究结果表明，用¹³¹ I合成的ZnPc和ZnPc-TiO ₂的放射标记产率很高。体外摄取研究表明，¹³¹ I-ZnPc-TiO ₂可能是乳腺癌和宫颈癌的核显像/治疗的潜在药物。根据PDT结果，ZnPc-TiO ₂可能是治疗宫颈肿瘤的潜在PDT药物。ZnPc和ZnPc‐TiO ₂ 可能被用作治疗治疗剂。