Herein we present a continuous flow reactor printed from stainless steel by selective laser melting. The reactor was specifically designed for a fast difluoromethylation reaction with nBuLi as base and fluoroform as atom-economic and inexpensive reagent. The reactor features four inlets to allow introduction of substrate, nBuLi, fluoroform, and a final quench solution. The reaction was completed within less than 2 min at −65 °C. The utilization of stainless steel as reactor material is critical to accomplish the heat transfer as well as the chemical and mechanical resistance that is required for this transformation.

中文翻译：

---

使用氟仿进行连续二氟甲基化的不锈钢反应器的设计和3D打印

本文中，我们介绍了一种由不锈钢通过选择性激光熔化印刷的连续流反应器。该反应器专门设计用于快速二氟甲基化反应，以正丁基锂为碱，氟仿为原子经济且廉价的试剂。该反应器具有四个入口，可引入底物，正丁基锂，氟仿和最终的淬灭溶液。在-65°C下，反应在不到2分钟的时间内完成。使用不锈钢作为反应器材料对于完成此转换所需的传热以及耐化学和机械阻力至关重要。