Biological network border detection,Integrative Biology

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Biological network border detection
Integrative Biology ( IF 1.5 ) Pub Date : 2017-11-01 00:00:00 , DOI: 10.1039/c7ib00161d
Paulo E. P. Burke _{1,

2,

3} , Cesar H. Comin _{2,

3,

4,

5} , Filipi N. Silva _{2,

3,

6,

7} , Luciano da F. Costa _{2,

3,

6,

7}

Affiliation

Complex networks have been widely used to model biological systems. The concept of accessibility has been proposed recently as a means to organize the nodes of complex networks as belonging to its border or center. Such an approach paves the way to investigating how the functional and structural properties of nodes vary with their respective position in the networks. In this work, we approach such a problem in a biological context applying border detection to Protein–Protein Interaction networks from four organisms of the Mycoplasma genus. We found evidence that the borderness of proteins bears a relation with their spatial organization and molecular function specificity.

中文翻译：

生物网络边界检测

复杂网络已被广泛用于对生物系统进行建模。最近已经提出了可访问性的概念，作为将复杂网络的节点组织为属于其边界或中心的一种手段。这种方法为研究节点的功能和结构特性如何随其在网络中的位置变化而铺平了道路。在这项工作中，我们在生物学上解决了这个问题，将边界检测应用于支原体属的四个生物体的蛋白质-蛋白质相互作用网络。我们发现证据表明蛋白质的边界与其空间组织和分子功能特异性有关。

更新日期：2017-11-15

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