Cover Feature: Protonation‐Initiated Cyclization by a Class II Terpene Cyclase Assisted by Tunneling (ChemBioChem 23/2017),ChemBioChem

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Cover Feature: Protonation‐Initiated Cyclization by a Class II Terpene Cyclase Assisted by Tunneling (ChemBioChem 23/2017)
ChemBioChem ( IF 2.6 ) Pub Date : 2017-11-15 , DOI: 10.1002/cbic.201700602
Adam Eriksson ₁ , Charlotte Kürten ₂ , Per-Olof Syrén _{1,

2}

Affiliation

The cover feature picture shows hydrogen tunneling during the initiation of polycyclization by protonation catalyzed by ent‐copalyl diphosphate synthase, a class II terpene cyclase. This previously unacknowledged feature of the remarkable biosynthetic mechanism could potentially be facilitated by the inherent “plastic” nature of terpene cyclases. In addition to substrate prefolding, as shown for geranylgeranyl diphosphate at the tunnel exit, enzyme‐assisted tunneling could be of importance in various terpene biocatalytic mechanisms for natural product biosynthesis. More information can be found in the communication by P.‐O. Syrén et al. on page 2301 in Issue 23, 2017. Image by Magnus Snickars (DOI: 10.1002/cbic.201700443).

中文翻译：

封面人物：通过隧道辅助的II类萜烯环化酶质子化引发的环化反应（ChemBioChem 23/2017）

封面的特征图片显示在多环戊二酸合磷酸酶（II类萜烯环化酶）催化的质子化作用下，多环化过程中的氢隧穿。萜烯环化酶固有的“可塑性”特性可能会促进这种非凡的生物合成机制先前未被认可的特征。除底物预折叠外，如隧道出口处的香叶基香叶基二磷酸香叶酯所示，酶促隧穿在天然产物生物合成的各种萜烯生物催化机制中可能也很重要。可以在P.O的通讯中找到更多信息。Syrén等。于2017年第23期的第2301页。图片来自Magnus Snickars（DOI：10.1002 / cbic.201700443）。

更新日期：2017-11-15

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