Ultrasensitive DNAzyme-Based Ca2+ Detection Boosted by Ethanol and a Solvent-Compatible Scaffold for Aptazyme Design,ChemBioChem

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Ultrasensitive DNAzyme-Based Ca2+ Detection Boosted by Ethanol and a Solvent-Compatible Scaffold for Aptazyme Design
ChemBioChem ( IF 2.6 ) Pub Date : 2017-11-14 12:55:54 , DOI: 10.1002/cbic.201700498
Tianmeng Yu ₁ , Wenhu Zhou _{1,

2} , Juewen Liu ₁

Affiliation

Alcoholic ion biosensor: Metal ions are often important for achieving the chemical functions DNAzymes. Generally, biosensors based on this functional DNA are tested in aqueous buffers, but introducing organic solvents can enhance the interaction between metal ions and DNA. The EtNa DNAzyme is highly sensitive to low concentrations of Ca²⁺ in ethanol as a cosolvent.

中文翻译：

乙醇和与溶剂兼容的支架可促进超灵敏的基于DNAzyme的Ca2 +检测，适用于Aptazyme设计。

酒精离子生物传感器：金属离子通常对于实现DNAzyme的化学功能很重要。通常，基于这种功能性DNA的生物传感器在水性缓冲液中进行测试，但是引入有机溶剂可以增强金属离子与DNA之间的相互作用。EtNa DNAzyme对作为助溶剂的乙醇中的Ca ²⁺低浓度高度敏感。

更新日期：2017-11-15

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