Sulfur helps! The first total synthesis of the title diterpene was accomplished starting from the Wieland–Miescher ketone. A diastereoselective sulfa-Michael addition enabled the generation of the delicate β,γ-unsaturated ketone moiety, while the tetracyclic kempane skeleton was readily constructed through domino metathesis.

中文翻译：

---

从高白蚁分离出的二萜3β-羟基-7β-kemp-8（9）-en-6-one的对映选择性全合成

硫磺有帮助！从Wieland-Miescher酮开始，完成了标题二萜的第一个全合成。非对映选择性的磺胺基-迈克尔基加成反应可生成精致的β，γ-不饱和酮部分，而四环丙烷骨架可通过多米诺复分解轻松构建。