Mesoporous 45S5 bioactive glass: synthesis, in vitro dissolution and biomineralization behavior,Journal of Materials Chemistry B

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Mesoporous 45S5 bioactive glass: synthesis, in vitro dissolution and biomineralization behavior
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2017-10-17 00:00:00 , DOI: 10.1039/c7tb01738c
Anil Kumar _{1,

2,

3} , Sevi Murugavel _{1,

2,

3} , Anusha Aditya _{3,

4,

5} , Aldo R. Boccaccini _{6,

7,

8}

Affiliation

The development of a new generation of biomaterials includes a sol–gel process to obtain glass foams, which is a well established method for CaO–SiO₂–P₂O₅ compositions, but is not yet recognized for Bioglass® containing sodium oxide. In this study, we report, for the first time, the synthesis of a mesoporous 45S5 bioactive glass with superior textural characteristics and its in vitro dissolution and biomineralization behavior. Wormhole-like bioactive mesostructured 45S5 glass has been synthesized by an acid assisted sol–gel method followed by an evaporation induced self-assembly process. The virgin mesoporous 45S5 bioactive glass has been characterized by various analytical methods before and after soaking in simulated body fluid (SBF). The factors affecting the glass formation have been discussed in terms of the critical micelle concentration (CMC) at a particular temperature followed by a specified time interval. In vitro studies on the mesostructured 45S5 glass sample reveal the rapid formation of carbonated hydroxyapatite (HCA) with nano sized crystals. The mesostructured glass showed an excellent cell proliferation response without toxicity up to the concentration of 50 μg ml⁻¹. Furthermore, we show that the 45S5 glass with superior textural parameters is extremely useful within the family of bioactive materials as it has accelerated formation kinetics of the apatite phase as compared to other bioactive glass compositions.

中文翻译：

中孔45S5生物活性玻璃：合成，体外溶解和生物矿化行为

新一代生物材料的开发包括通过溶胶-凝胶工艺获得玻璃泡沫，这是一种针对CaO-SiO ₂ -P ₂ O ₅组合物的成熟方法，但尚未被含氧化钠的Bioglass®所认可。在这项研究中，我们首次报告了具有优异质地特性的介孔45S5生物活性玻璃的合成及其体外溶解和生物矿化行为。蠕虫状具有生物活性的介观结构的45S5玻璃是通过酸辅助溶胶-凝胶法合成，然后进行蒸发诱导的自组装过程。在浸入模拟体液（SBF）之前和之后，已通过各种分析方法对纯中孔45S5生物活性玻璃进行了表征。已经讨论了影响玻璃形成的因素，包括在特定温度下紧随指定时间间隔后的临界胶束浓度（CMC）。对介孔结构45S5玻璃样品的体外研究表明，具有纳米级晶体的碳酸羟基磷灰石（HCA）迅速形成。介孔玻璃在浓度高达50μg/ ml时显示出优异的细胞增殖反应而无毒性^-1。此外，我们显示出具有优异质地参数的45S5玻璃在生物活性材料家族中极为有用，因为与其他生物活性玻璃组合物相比，它具有加快磷灰石相形成动力学的作用。

更新日期：2017-11-15

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