Sharp convex gold grooves for fluorescence enhancement in micro/nano fluidic biosensing,Journal of Materials Chemistry B

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Sharp convex gold grooves for fluorescence enhancement in micro/nano fluidic biosensing
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2017-10-17 00:00:00 , DOI: 10.1039/c7tb02422c
Zhi-Hui Chen _{1,

2,

3,

4,

5} , Hua Shi _{1,

2,

3,

4,

5} , Yang Wang _{6,

7,

8,

9} , Yibiao Yang _{1,

2,

3,

4,

5} , Shaoding Liu _{1,

2,

3,

4,

5} , Han Ye _{9,

10,

11,

12}

Affiliation

The enhancement of biosensing sensitivity based on a quantum dot (QD) is limited by the long distance between the QD and the substrate in in vitro detection, which prevents the development of biosensors. Here an individual sharp convex gold groove is proposed to enhance remote fluorescence by exciting and collecting fluorescence efficiently. The structure shows a higher emission power than other wider gold groove structures when the QD is individually placed at five random positions inside the groove. Compared with bare glass, the total power enhancement factor of our structure is up to 17.0 times, 6.6 times and 6.4 times when the QD is 3.5 μm, 7.6 μm and 9.0 μm away from the bottom of the groove, respectively, due to the scattered emission of the QD and guided resonance modes inside the groove. In addition, the structure is easy to fabricate. The individual sharp convex gold groove is expected to be used as one unit of multi-channels in micro/nano fluidic biosensing. The sample volume could be very small or large according to real applications due to the particular geometric features of our structure.

中文翻译：

锋利的凸形金槽，可在微/纳米流体生物传感中增强荧光

基于量子点（QD）的生物传感灵敏度的增强受到体外QD与底物之间长距离的限制检测，阻止了生物传感器的发展。在这里，提出了一个单独的尖锐的凸金槽，以通过有效激发和收集荧光来增强远程荧光。当将QD单独放置在凹槽内部的五个随机位置时，该结构显示出比其他较宽的金凹槽结构更高的发射功率。与裸露的玻璃相比，当QD距凹槽底部为3.5μm，7.6μm和9.0μm时，由于散射，我们的结构的总功率增强因子分别高达17.0倍，6.6倍和6.4倍。 QD的发射和凹槽内的引导共振模式。另外，该结构易于制造。有望在微/纳米流体生物传感中将单个尖锐的凸形金槽用作多通道的一个单元。

更新日期：2017-11-15

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