Coordination polymer hybridized Au nanocages: a nanoplatform for dual-modality imaging guided near-infrared driven photothermal therapy in vivo,Journal of Materials Chemistry B

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Coordination polymer hybridized Au nanocages: a nanoplatform for dual-modality imaging guided near-infrared driven photothermal therapy in vivo
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2017-10-12 00:00:00 , DOI: 10.1039/c7tb02302b
Congyang Yan _{1,

2,

3,

4,

5} , Lili Cui _{1,

2,

3,

4,

5} , Qi Yang _{1,

2,

3,

4,

5} , Xiaobao Zhou _{1,

2,

3,

4,

5} , Lixing Pan _{1,

2,

3,

4,

5} , Xiaofen Zhang _{1,

2,

3,

4,

5} , Hong Yang _{1,

2,

3,

4,

5} , Zhiguo Zhou _{1,

2,

3,

4,

5} , Shiping Yang _{1,

2,

3,

4,

5}

Affiliation

Coordination polymer hybridized Au nanocages (AuNC@CPs) were prepared via a dialysis process by combining Au nanocages with a coordination polymer, which was derived from (pq)₂Ir(Hdcbpy) and Dy(OOCCH₃)₃. After hybridization, the localized surface plasmon resonance (LSPR) peak of the AuNC@CPs exhibited an evident red shift in comparison with that of the Au nanocages, which was due to a variation in the dielectric constant caused by the coordination polymer. Notably, inspired by their excellent photothermal, photoacoustic, and magnetic properties in solution, AuNC@CPs were used for near-infrared (NIR)-driven photothermal therapy (PTT) guided by photoacoustic (PA) and magnetic resonance (MR) imaging in vivo. Owing to their remarkable performance, the AuNC@CPs would represent promising nanoprobes for theranostics.

中文翻译：

配位聚合物杂交金纳米笼：用于双模态成像的纳米平台，在体内指导近红外驱动的光热疗法

通过将金纳米笼与衍生自（pq）₂ Ir（Hdcbpy）和Dy（OOCCH ₃）₃的配位聚合物结合，通过渗析工艺制备了配位聚合物杂化的金纳米笼（AuNC @ CPs）。杂交后，与Au纳米笼相比，AuNC @ CPs的局部表面等离子体共振（LSPR）峰表现出明显的红移，这是由于配位聚合物引起的介电常数变化。值得注意的是，受到溶液中出色的光热，光声和磁性的启发，AuNC @ CP被用于体内的光声（PA）和磁共振（MR）成像指导的近红外（NIR）驱动的光热疗法（PTT）。由于其出色的性能，AuNC @ CPs代表了用于诊断学的有前途的纳米探针。

更新日期：2017-11-15

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