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In vitro degradation behavior of a hydroxyapatite/poly(lactide-co-glycolide) composite reinforced by micro/nano-hybrid poly(glycolide) fibers for bone repair
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2017-10-11 00:00:00 , DOI: 10.1039/c7tb02364b Yuhang Zhu 1, 2, 3, 4, 5 , Zongliang Wang 1, 2, 3, 4, 5 , Linlong Li 1, 2, 3, 4, 5 , Daqian Gao 1, 2, 3, 4, 5 , Qinli Xu 1, 2, 3, 4, 5 , Qingsan Zhu 5, 6, 7, 8, 9 , Peibiao Zhang 1, 2, 3, 4, 5
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2017-10-11 00:00:00 , DOI: 10.1039/c7tb02364b Yuhang Zhu 1, 2, 3, 4, 5 , Zongliang Wang 1, 2, 3, 4, 5 , Linlong Li 1, 2, 3, 4, 5 , Daqian Gao 1, 2, 3, 4, 5 , Qinli Xu 1, 2, 3, 4, 5 , Qingsan Zhu 5, 6, 7, 8, 9 , Peibiao Zhang 1, 2, 3, 4, 5
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A poly(glycolide) (PGA) fiber-reinforced hydroxyapatite/poly(lactide-co-glycolide) (HA/PLGA) composite with high mechanical strength has been prepared previously. In this paper, in vitro degradation of ternary composites with different contents of PGA fibers (0, 30, 50 and 70 wt%) was investigated. Water absorption showed a marked increase as the degradation progressed, and the composite with 70 wt% PGA fibers showed the highest final water uptake which was 3.89 times higher than the initial value. The mass loss of the composite with 70 wt% PGA fibers was 79.3 ± 6.47% at 16 weeks, which was the highest among all the composites. The molecular weight of the PLGA matrix decreased over time especially for the composites containing 70 wt% PGA fibers. The lowest pH of the buffer solution was also observed in the composite with 70 wt% PGA fibers. Environmental scanning electron microscopy (ESEM) and micro-computed tomography (micro-CT) results demonstrated that the porosity of the composites and the size of the pores gradually increased as the degradation progressed. The most significant change in compression strength was observed for the composite with 70 wt% PGA fibers which was reduced from an initial value of 20 MPa to approximately 1 MPa at 16 weeks. The results indicated that the in vitro degradation of the composites could be accelerated by increasing the content of PGA fibers. It implied that the ternary composites might be a candidate for the repair of non-load bearing or cancellous bone which needs high initial strength and fast degradation rate.
中文翻译：
体外羟基磷灰石/聚降解行为（丙交酯-共-glycolide）复合材料的微/纳米杂化聚增强（乙交酯）纤维用于骨修复
聚（乙交酯）（PGA）纤维增强羟基磷灰石/聚（丙交酯-共-glycolide）（HA / PLGA）复合具有高机械强度已预先制备。在本文中，体外研究了不同含量的PGA纤维（0、30、50和70 wt％）的三元复合材料的降解性能。吸水率随着降解的进行而显着增加，具有70 wt％PGA纤维的复合材料显示出最高的最终吸水率，是初始值的3.89倍。具有70 wt％PGA纤维的复合材料的质量损失在16周时为79.3±6.47％，这是所有复合材料中最高的。PLGA基质的分子量随时间降低，特别是对于包含70重量％PGA纤维的复合材料而言。在含有70 wt％PGA纤维的复合材料中也观察到了缓冲溶液的最低pH值。环境扫描电子显微镜（ESEM）和计算机断层扫描（micro-CT）结果表明，随着降解的进行，复合材料的孔隙率和孔的大小逐渐增加。观察到具有70 wt％PGA纤维的复合材料的压缩强度发生了最显着的变化，在16周时从20 MPa的初始值降低到大约1 MPa。结果表明复合材料的体外降解可以通过增加PGA纤维的含量来加速。这表明三元复合材料可能是修复非承重或松质骨的候选材料，这些骨需要高的初始强度和快速的降解速率。
更新日期：2017-11-15
中文翻译：
体外羟基磷灰石/聚降解行为（丙交酯-共-glycolide）复合材料的微/纳米杂化聚增强（乙交酯）纤维用于骨修复
聚（乙交酯）（PGA）纤维增强羟基磷灰石/聚（丙交酯-共-glycolide）（HA / PLGA）复合具有高机械强度已预先制备。在本文中，体外研究了不同含量的PGA纤维（0、30、50和70 wt％）的三元复合材料的降解性能。吸水率随着降解的进行而显着增加，具有70 wt％PGA纤维的复合材料显示出最高的最终吸水率，是初始值的3.89倍。具有70 wt％PGA纤维的复合材料的质量损失在16周时为79.3±6.47％，这是所有复合材料中最高的。PLGA基质的分子量随时间降低，特别是对于包含70重量％PGA纤维的复合材料而言。在含有70 wt％PGA纤维的复合材料中也观察到了缓冲溶液的最低pH值。环境扫描电子显微镜（ESEM）和计算机断层扫描（micro-CT）结果表明，随着降解的进行，复合材料的孔隙率和孔的大小逐渐增加。观察到具有70 wt％PGA纤维的复合材料的压缩强度发生了最显着的变化，在16周时从20 MPa的初始值降低到大约1 MPa。结果表明复合材料的体外降解可以通过增加PGA纤维的含量来加速。这表明三元复合材料可能是修复非承重或松质骨的候选材料，这些骨需要高的初始强度和快速的降解速率。
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