Design and preparation of 90Y-labeled imidodiphosphate- and inositol hexaphosphate-coated magnetic nanoparticles for possible medical applications,Journal of Materials Chemistry B

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Design and preparation of 90Y-labeled imidodiphosphate- and inositol hexaphosphate-coated magnetic nanoparticles for possible medical applications
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2017-10-11 00:00:00 , DOI: 10.1039/c7tb02075a
Magdalena Radović _{1,

2,

3,

4,

5} , Marija Mirković _{1,

2,

3,

4,

5} , Marko Perić _{1,

2,

3,

4,

5} , Drina Janković _{1,

2,

3,

4,

5} , Aleksandar Vukadinović _{1,

2,

3,

4,

5} , Dragana Stanković _{1,

2,

3,

4,

5} , Đorđe Petrović _{1,

2,

3,

4,

5} , Marko Bošković _{2,

3,

4,

5,

6} , Bratislav Antić _{2,

3,

4,

5,

6} , Mirjana Marković _{2,

3,

4,

5,

7} , Sanja Vranješ-Đurić _{1,

2,

3,

4,

5}

Affiliation

Radiolabeled magnetic nanoparticles (MNPs) coated with hydrophilic phosphate ligands, i.e., imidodiphosphate (IDP) and inositol hexaphosphate (IHP), were developed as multifunctional agents to localize both radioactivity and magnetic energy at a tumor site. The coating of MNPs with phosphates made them biocompatible, increased their colloidal stability and allowed binding of the radionuclide ⁹⁰Y to the available functional groups on the surface of the MNPs. IDP and IHP have not hitherto been used for the coating of MNPs and the results of this study of the functionalized MNPs showed that the phosphate groups influenced the modification of the surface of MNPs. Characterization of the MNPs was performed using X-ray powder diffraction, transmission electron microscopy, Fourier transform infrared spectroscopy, dynamic light scattering and laser Doppler electrophoresis. The specific power absorption values obtained for MNPs (46.95–80.76 W g⁻¹) in different physiological media indicated their possible application in hyperthermia treatment. Both types of coated MNPs were ⁹⁰Y-labeled in a reproducible high yield (>98%). In vitro studies of ⁹⁰Y-MNPs in saline and human serum showed their high stability after 72 h. The biodistribution pattern of the MNPs after intravenous administration to healthy Wistar rats was followed by the radiotracer method, revealing that ⁹⁰Y-Fe₃O₄-IDP and ⁹⁰Y-Fe₃O₄-IHP MNPs were predominantly found in the liver (85.21% ID and 86.22% ID), followed by the spleen (9.23% ID and 8.82% ID) and the lungs (1.53% ID and 1.53% ID). The results of this comprehensive study showed that radiolabeled biocompatible phosphate magnetic complexes hold great promise for therapeutic uses combining magnetic hyperthermia and radiotherapy.

中文翻译：

⁹⁰ Y标记的亚氨基二磷酸和肌醇六磷酸涂层磁性纳米颗粒的设计和制备

已开发出涂覆有亲水性磷酸酯配体（即亚氨基二磷酸酯（IDP）和肌醇六磷酸酯（IHP））的放射性标记磁性纳米颗粒（MNP）作为多功能剂，可将放射性和磁能定位在肿瘤部位。MNPs的磷酸盐涂层使它们具有生物相容性，增加了其胶体稳定性，并允许放射性核素^90的结合Y表示MNP表面上的可用官能团。迄今为止，IDP和IHP尚未用于MNPs的涂层，对功能化MNPs的研究结果表明，磷酸基团影响MNPs的表面修饰。使用X射线粉末衍射，透射电子显微镜，傅立叶变换红外光谱，动态光散射和激光多普勒电泳对MNP进行表征。在不同的生理介质中获得的MNP（46.95–80.76 W g ^-1）的比功率吸收值表明它们可能在热疗中应用。两种类型的包被的MNP都以可重现的高产率（> 98％）进行了⁹⁰ Y标记。^90的体外研究生理盐水和人血清中的Y-MNP在72小时后显示出高稳定性。放射性示踪法追踪了向健康Wistar大鼠静脉内给药后MNP的生物分布模式，发现肝脏中主要发现⁹⁰ Y-Fe ₃ O ₄ -IDP和⁹⁰ Y-Fe ₃ O ₄ -IHP MNPs（85.21内脏百分比（％ID和86.22％ID），其次是脾脏（9.23％ID和8.82％ID）和肺部（1.53％ID和1.53％ID）。这项全面研究的结果表明，放射性标记的生物相容性磷酸磁性复合物在磁热疗和放射疗法相结合的治疗用途方面具有广阔的前景。

更新日期：2017-11-15

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