[18F]ODIBO: a prosthetic group for bioorthogonal radiolabeling of macromolecules via strain-promoted alkyne–azide cycloaddition†,Organic & Biomolecular Chemistry

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[18F]ODIBO: a prosthetic group for bioorthogonal radiolabeling of macromolecules via strain-promoted alkyne–azide cycloaddition†
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2017-11-15 00:00:00 , DOI: 10.1039/c7ob02532g
Mehdi Boudjemeline _{1,

2,

3,

4,

5} , Christopher D. McNitt _{6,

7,

8,

9} , Thomas A. Singleton _{1,

2,

3,

4,

5} , Vladimir V. Popik _{6,

7,

8,

9} , Alexey P. Kostikov _{1,

2,

3,

4,

5}

Affiliation

A novel prosthetic group for the efficient radiolabeling of macromolecules has been developed. [¹⁸F]oxadibenzocyclooctyne ([¹⁸F]ODIBO) is synthesized in high radiochemical yield and applied for nearly quantitative conjugation to azide-tagged peptides and proteins at room temperature and low substrate concentrations. The resulting bioconjugates are chemically and radiochemically pure and free of toxic solvents and catalysts.

中文翻译：

[ ¹⁸ F] ODIBO：通过应变促进炔烃-叠氮化物环加成对大分子进行生物正交放射标记的人工修复体†

已经开发出一种用于大分子有效放射性标记的新型假体。[ ¹⁸ F]恶二苯并环辛炔（[ ¹⁸ F] ODIBO）以高放射化学产率合成，并在室温和低底物浓度下几乎定量地与叠氮化物标记的肽和蛋白质偶联。所得的生物缀合物在化学和放射化学上是纯净的，并且没有毒性溶剂和催化剂。

更新日期：2017-11-15

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