Mesoporous silica nanoparticles incorporating squaraine-based photosensitizers: a combined experimental and computational approach,Dalton Transactions

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Mesoporous silica nanoparticles incorporating squaraine-based photosensitizers: a combined experimental and computational approach
Dalton Transactions ( IF 3.5 ) Pub Date : 2017-10-31 00:00:00 , DOI: 10.1039/c7dt03735j
Ivana Miletto _{1,

2,

3,

4} , Alberto Fraccarollo _{1,

2,

3,

4} , Nadia Barbero _{4,

5,

6,

7} , Claudia Barolo _{4,

5,

6,

7} , Maurizio Cossi _{1,

2,

3,

4} , Leonardo Marchese _{1,

2,

3,

4} , Enrica Gianotti _{1,

2,

3,

4}

Affiliation

Squaraine dyes, that exhibit intense absorption in the red/near infrared region, have been successfully introduced into mesoporous silica nanoparticles (MSNs) to obtain a nanoplatform for photodynamic therapy. Three brominated squaraine dyes which exhibited good PS performance in solution but a different behaviour in vitro due to cell permeability issues were used as photosensitizers. The effects of the adsorption within the pores of MSNs on the overall UV-Vis-NIR absorption and emission properties as well as on the PS performance was evaluated via a combined experimental and computational physico-chemical approach, which allowed us to correlate the unusual optical properties of two out of three systems with the dimerization of squaraines on the silica surface, with detrimental effects on the PS performance. Conversely, the nanoplatform where the squaraine molecules are adsorbed as monomers on the silica surface exhibited the best activity in singlet oxygen generation.

中文翻译：

结合基于方酸的光敏剂的中孔二氧化硅纳米粒子：结合实验和计算方法

在红色/近红外区域表现出强烈吸收的方蓝染料已成功引入介孔二氧化硅纳米颗粒（MSN）中，从而获得了用于光动力疗法的纳米平台。三种在溶液中表现出良好PS性能但由于细胞通透性问题而在体外具有不同行为的溴化方酸染料被用作光敏剂。通过以下方法评估了MSN孔内吸附对整体UV-Vis-NIR吸收和发射性能以及PS性能的影响结合了实验和计算的物理化学方法，这使我们能够将三个系统中的两个系统的异常光学特性与二氧化硅表面上的方括号的二聚化相关联，从而对PS性能产生不利影响。相反，将方酸分子作为单体吸附在二氧化硅表面的纳米平台在单线态氧的产生中表现出最佳的活性。

更新日期：2017-11-15

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