Synthesis and characterization of chitosan-coated titanate nanotubes: towards a new safe nanocarrier,Dalton Transactions

当前位置： X-MOL 学术 › Dalton Trans. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Synthesis and characterization of chitosan-coated titanate nanotubes: towards a new safe nanocarrier
Dalton Transactions ( IF 3.5 ) Pub Date : 2017-10-13 00:00:00 , DOI: 10.1039/c7dt03029k
Fadoua Sallem _{1,

2,

3,

4,

5} , Julien Boudon _{6,

7,

8,

9} , Olivier Heintz _{6,

7,

8,

9} , Isabelle Séverin _{10,

11,

12,

13,

14} , Adel Megriche _{1,

2,

3,

4,

5} , Nadine Millot _{6,

7,

8,

9}

Affiliation

In this work, we discuss for the first time the elaboration of nanohybrid materials, intended for drug delivery systems, based on titanate nanotubes (TiONts) coated with chitosan polymer (CT). Chitosan has been used to enhance the biocompatibility of hydrothermally synthesized nanotubes in biological medium as a substitute for the polyethylene glycol (PEG) that is generally used for biocompatibility. CT grafting was carried out using two different approaches; the first was made by a covalent bond using two intermediate molecules, and the second is based on electrostatic interactions between CT and TiONts. The type of elaborated bond on the surface of TiONts was proven to influence the colloidal stability of the elaborated nanohybrids, which were studied in different media. A detailed comparison between these two approaches was carried by XPS and TGA-SM techniques. Finally, an original and sensitive cytotoxicity assay consisting of the measurement of the cells’ total RNA synthesis was used to prove the non-toxicity of both obtained nanohybrids.

中文翻译：

壳聚糖包覆的钛酸酯纳米管的合成与表征：向新型安全纳米载体的方向发展

在这项工作中，我们首次讨论了基于壳聚糖聚合物（CT）涂层的钛酸酯纳米管（TiONts）的纳米混合材料的制备，该材料用于药物递送系统。壳聚糖已被用来增强生物介质中水热合成纳米管的生物相容性，以代替通常用于生物相容性的聚乙二醇（PEG）。CT移植使用两种不同的方法进行：第一个是通过使用两个中间分子的共价键制成的，第二个是基于CT和TiONts之间的静电相互作用的。TiONts表面的精细键的类型被证明会影响精细纳米杂化物的胶体稳定性，已在不同介质中对其进行了研究。XPS和TGA-SM技术对这两种方法进行了详细的比较。最后，通过对细胞总RNA合成的测量，对细胞毒性进行了原始而敏感的测定，以证明两种获得的纳米杂交体均无毒。

更新日期：2017-11-15

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11