Click Chemistry: Mechanistic Insights into the Role of Amines Using Single-Molecule Spectroscopy,ACS Catalysis

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Click Chemistry: Mechanistic Insights into the Role of Amines Using Single-Molecule Spectroscopy
ACS Catalysis ( IF 11.3 ) Pub Date : 2017-11-14 00:00:00 , DOI: 10.1021/acscatal.7b03150
Bowen Wang ₁ , Anabel E. Lanterna ₁ , Juan C. Scaiano ₁

Affiliation

Single-molecule spectroscopy is used to gain insights into the click chemistry reaction photocatalyzed by copper. We show that Cu_xO@Nb₂O₅ catalysts can act as truly heterogeneous photocatalysts and that the amine plays an important role in the complexation between the alkyne and the copper active site on the catalyst surface. For complex reactions occurring in the subnanomolar range, preassociation can be essential and cocatalysts (such as amines here) may play an enabling role facilitating the reagents “reunion” and prolonging the time available for reaction. This provides a rational analysis of the amine role in heterogeneous photocatalytic click chemistry.

中文翻译：

单击化学：使用单分子光谱对胺的作用进行机械分析

单分子光谱法用于深入了解铜光催化的点击化学反应。我们表明，Cu _x O @ Nb ₂ O ₅催化剂可以充当真正的多相光催化剂，并且胺在炔烃和催化剂表面铜活性位之间的络合中起重要作用。对于在亚纳摩尔范围内发生的复杂反应，预缔合可能是必不可少的，助催化剂（如此处的胺类）可能在促进试剂“重聚”并延长可用于反应的时间方面起促进作用。这提供了胺在非均相光催化点击化学中的作用的合理分析。

更新日期：2017-11-15

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