Direct UV-Triggered Thiol–ene Cross-Linking of Electrospun Polyester Fibers from Unsaturated Poly(macrolactone)s and Their Drug Loading by Solvent Swelling,Biomacromolecules

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Direct UV-Triggered Thiol–ene Cross-Linking of Electrospun Polyester Fibers from Unsaturated Poly(macrolactone)s and Their Drug Loading by Solvent Swelling
Biomacromolecules ( IF 5.5 ) Pub Date : 2017-11-14 00:00:00 , DOI: 10.1021/acs.biomac.7b01335
Fernando C. S. de Oliveira ₁ , Dinorath Olvera ₂ , Michael J. Sawkins ₂ , Sally-Ann Cryan _{2,

3} , Scott D. Kimmins ₁ , Tatiane Eufrasio da Silva _{2,

3,

4} , Daniel J. Kelly _{3,

4,

5} , Garry P. Duffy _{2,

3,

4,

6} , Cathal Kearney _{3,

4} , Andreas Heise ₁

Affiliation

Electrospinning is considered a relatively simple and versatile technique to form high porosity porous scaffolds with micron to nanoscale fibers for biomedical applications. Here, electrospinning of unsaturated aliphatic polyglobalide (PGl) into well-defined fibers with an average diameter of 9 μm is demonstrated. Addition of a dithiol cross-linker and a photoinitiator to the polymer solution enabled the UV-triggered intracross-linking of the fibers during the spinning process. The in situ cross-linking of the fibers resulted in amorphous material able to swell up to 14% in tetrahydrofurane (THF) without losing the fiber morphology. Seeding mesenchymal stem cells (MSCs) onto both cross-linked and non-cross-linked PGl fibers proved their compatibility with MSCs and suitability as scaffolds for cell growth and proliferation of MSCs. Moreover, the ability to directly load cross-linked PGl with hydrophobic molecules by soaking the fiber mesh in solution is shown with Rhodamine B and Indomethacin, a hydrophobic anti-inflammatory drug. This marks an advantage over conventional aliphatic polyesters and opens opportunities for the design of drug loaded polyester scaffolds for biomedical applications or tissue engineering.

中文翻译：

直接紫外线引发的不饱和聚（内酯）电纺聚酯纤维的巯基-烯交联及其溶剂溶胀的载药量

电纺丝被认为是相对简单且通用的技术，以形成用于生物医学应用的具有微米至纳米级纤维的高孔隙率多孔支架。在此，证明了将不饱和脂肪族聚Globalide（PG1）电纺成平均直径为9μm的纤维。在聚合物溶液中添加二硫醇交联剂和光引发剂，可以在纺丝过程中通过紫外线触发纤维的内部交联。纤维的原位交联导致无定形材料能够在四氢呋喃（THF）中溶胀达14％，而不会失去纤维的形态。将间充质干细胞（MSC）接种到交联和非交联的PG1纤维上，证明了它们与MSC的相容性，以及作为细胞生长和增殖的支架的适用性。而且，通过罗丹明B和疏水消炎药吲哚美辛显示了通过将纤维网浸泡在溶液中将疏水分子直接装载到交联的PG1上的能力。这标志着优于常规脂族聚酯的优势，并为设计用于生物医学应用或组织工程的载药聚酯支架提供了机会。

更新日期：2017-11-14

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