Nickel-Catalyzed 1,2-Aminoarylation of Oxime Ester-Tethered Alkenes with Boronic Acids,ACS Catalysis

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Nickel-Catalyzed 1,2-Aminoarylation of Oxime Ester-Tethered Alkenes with Boronic Acids
ACS Catalysis ( IF 11.3 ) Pub Date : 2017-11-13 00:00:00 , DOI: 10.1021/acscatal.7b03432
Hai-Bin Yang ₁ , Stalin R. Pathipati ₁ , Nicklas Selander ₁

Affiliation

A nickel-catalyzed 1,2-aminoarylation of oxime-ester-tethered alkenes with boronic acids was developed. A variety of pyrroline derivatives were synthesized in good yields via the successive formation of C(sp³)–N and C(sp³)–C(sp²) bonds. For cyclobutanone-derived oxime esters, the reaction provided aliphatic nitriles incorporating an aromatic group in the γ-position. A mechanism involving iminyl radical and carbon-centered radical intermediates was proposed.

中文翻译：

肟催化的硼酸酯对镍催化的肟酯系烯烃的1,2-氨基芳基化

开发了镍催化的肟酯系链烯烃与硼酸的镍催化1，2-氨基芳基化反应。通过连续形成C（sp ³）–N和C（sp ³）–C（sp ²）键，可以合成高产率的各种吡咯啉衍生物。对于环丁酮衍生的肟酯，该反应提供了在γ位上结合有芳族基团的脂族腈。提出了涉及亚胺基和以碳为中心的自由基中间体的机理。

更新日期：2017-11-14

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