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Enzymatic Incorporation of Modified Purine Nucleotides in DNA
ChemBioChem ( IF 3.2 ) Pub Date : 2017-11-14 04:20:25 , DOI: 10.1002/cbic.201700393
Rania Abu El Asrar 1 , Lia Margamuljana 1 , Mikhail Abramov 1 , Omprakash Bande 1 , Stefano Agnello 1, 2 , Miyeon Jang 1 , Piet Herdewijn 1
Affiliation  

How will I recognize you? N8-Glycosylated nucleosides (with an 8-azaguanine or 8-aza-9-deazaguanine base moiety) are recognized by DNA polymerases for pairing with 5-methylisocytosine or 8-substituted hypoxanthine bases. The N9 atom of the N8-linked nucleosides significantly affects base-pair recognition, selective pairing (against recognition by natural bases), and the ability of the N8-nucleosides to form a self-complementary pair.

中文翻译:

酶促修饰的嘌呤核苷酸在DNA中的掺入

我怎么认出你? DNA聚合酶识别N 8-糖基化的核苷(具有8-氮杂鸟嘌呤或8-氮杂9-脱氮鸟嘌呤碱基),以与5-甲基异胞嘧啶或8-取代的次黄嘌呤碱基配对。N 8-连接的核苷的N 9原子显着影响碱基对的识别,选择性配对(反对天然碱基的识别)以及N 8-核苷形成自互补对的能力。
更新日期:2017-11-14
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