Unprecedented Sensitivity in a Probe for Monitoring Cathepsin B: Chemiluminescence Microscopy Cell-Imaging of a Natively Expressed Enzyme,Angewandte Chemie International Edition

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Unprecedented Sensitivity in a Probe for Monitoring Cathepsin B: Chemiluminescence Microscopy Cell-Imaging of a Natively Expressed Enzyme
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2017-11-14 02:40:53 , DOI: 10.1002/anie.201709347
Michal E. Roth-Konforti ₁ , Christoph R. Bauer ₂ , Doron Shabat ₁

Affiliation

Chemiluminescence cell-imaging: The first chemiluminescence probe for the detection of cathepsin B is described. The probe showed unprecedented sensitivity compared to that of a classic fluorescent probe for cathepsin B and provided the first chemiluminescence microscopy cell images of a natively expressed enzyme, enabling the differentiation between cancerous cells and normal tissue.

中文翻译：

监测组织蛋白酶B的探头中前所未有的敏感性：天然表达的酶的化学发光显微镜细胞成像。

化学发光细胞成像：描述了用于检测组织蛋白酶B的第一种化学发光探针。与经典的组织蛋白酶B探针相比，该探针显示出前所未有的灵敏度，并且提供了天然表达的酶的第一化学发光显微镜细胞图像，从而能够区分癌细胞和正常组织。

更新日期：2017-11-14

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