Decellularized Matrices As Cell-Instructive Scaffolds to Guide Tissue-Specific Regeneration,ACS Biomaterials Science & Engineering

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Decellularized Matrices As Cell-Instructive Scaffolds to Guide Tissue-Specific Regeneration
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2017-11-13 00:00:00 , DOI: 10.1021/acsbiomaterials.7b00619
Kevin P. Robb ₁ , Arthi Shridhar ₂ , Lauren E. Flynn _{2,

3}

Affiliation

Decellularized scaffolds are promising clinically translational biomaterials that can be applied to direct cell responses and promote tissue regeneration. Bioscaffolds derived from the extracellular matrix (ECM) of decellularized tissues can naturally mimic the complex extracellular microenvironment through the retention of compositional, biomechanical, and structural properties specific to the native ECM. Increasingly, studies have investigated the use of ECM-derived scaffolds as instructive substrates to recapitulate properties of the stem cell niche and guide cell proliferation, paracrine factor production, and differentiation in a tissue-specific manner. Here, we review the application of decellularized tissue scaffolds as instructive matrices for stem or progenitor cells, with a focus on the mechanisms through which ECM-derived scaffolds can mediate cell behavior to promote tissue-specific regeneration. We conclude that although additional preclinical studies are required, ECM-derived scaffolds are a promising platform to guide cell behavior and may have widespread clinical applications in the field of regenerative medicine.

中文翻译：

脱细胞基质作为指导细胞特异性再生的细胞指导性支架

脱细胞支架是有前途的临床翻译生物材料，可用于指导细胞反应并促进组织再生。源自脱细胞组织的细胞外基质（ECM）的生物支架可以通过保留天然ECM特有的组成，生物力学和结构特性来自然模拟复杂的细胞外微环境。越来越多的研究研究了使用ECM衍生的支架作为指导性底物，以概括干细胞生态位的特性并以组织特异性方式指导细胞增殖，旁分泌因子的产生和分化。在这里，我们回顾了脱细胞组织支架作为干细胞或祖细胞指导性基质的应用，着重于ECM衍生支架可介导细胞行为以促进组织特异性再生的机制。我们得出结论，尽管还需要进行其他的临床前研究，但ECM衍生的支架是指导细胞行为的有前途的平台，并且在再生医学领域可能具有广泛的临床应用。

更新日期：2017-11-13

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