Abstract A strategy based on the synergistic effect of polyhedral oligomeric silsesquioxane (POSS) and liquid crystal (LC) was described to prepare molecularly imprinted polymers (MIPs). A typical polymerization system was composed of 4-methyl phenyl dicyclohexyl ethylene (MPDE)(LC monomer), methacryllsobutyl POSS (POSS monomer), methacrylic acid, as well as ethylene glycol dimethacrylate (EDMA). The cooperative effect of LC and POSS was demonstrated by comparing the adsoption amount and imprinting factor of the LC POSS MIPs with that of other MIPs prepared using only LC or POSS monomer, as well as MIP made without LC and POSS. The influence of the content of POSS, the ratio of the template to functional monomer as well as the types of LC monomer on imprinting performance was investigated. A detailed morphology study of the MIPs displayed that the simultaneous use of LC and POSS monomer to prepare MIPs also produced the changes in pore structure different from the use of LC or POSS monomer independently. The reinforced imprinted effect of LC POSS MIPs against paclitaxel (PTX) was also approved by superior controlled release characteristics through analyzing the PTX release kinetics. The cytotoxicity of each polymer was lower than the drug-loaded polymer, which was measured by using the MTT assay with human breast cancer cell (MCF-7 cell). Compared with pure PTX, LC POSS MIPs displayed a higher relative bioavailability of 242.5%, while the LC POSS-free control MIPs and POSS LC-free control MIPs only 127.4 and 63.2%, respectively.

中文翻译：

---

液晶和多面体低聚倍半硅氧烷的协同作用制备用于紫杉醇递送的分子印迹聚合物

摘要 描述了一种基于多面体低聚倍半硅氧烷 (POSS) 和液晶 (LC) 协同效应制备分子印迹聚合物 (MIP) 的策略。典型的聚合体系由4-甲基苯基二环己基乙烯（MPDE）（LC单体）、甲基丙烯酰基异丁基POSS（POSS单体）、甲基丙烯酸以及乙二醇二甲基丙烯酸酯（EDMA）组成。通过比较LC POSS MIPs与仅使用LC或POSS单体制备的其他MIPs以及没有LC和POSS制备的MIPs的吸附量和印迹因子，证明了LC和POSS的协同作用。研究了POSS的含量、模板与功能单体的比例以及LC单体的类型对印迹性能的影响。MIP 的详细形态研究表明，同时使用 LC 和 POSS 单体制备 MIP 也产生了不同于单独使用 LC 或 POSS 单体的孔结构变化。通过分析 PTX 释放动力学，LC POSS MIP 对紫杉醇 (PTX) 的增强印迹效应也得到了优异的控释特性的认可。每种聚合物的细胞毒性均低于载药聚合物，这是通过使用人乳腺癌细胞（MCF-7 细胞）的 MTT 法测定的。与纯 PTX 相比，LC POSS MIPs 显示出更高的相对生物利用度，为 242.5%，而 LC POSS-free 对照 MIPs 和 POSS LC-free 对照 MIPs 分别只有 127.4% 和 63.2%。