The method for difluoromethylation of parent azoles, namely pyrrole, 1,2,3-triazole, 1,2,4-triazole and tetrazole was developed. Difluorometylation of pyrrole and 1,2,3-triazole was performed by action of chlorodifluoromethane. Sodium chlorodifluoroacetate was used as a difluoromethylation agent for 1,2,4-triazole and tetrazole. N-Difluoromethyl derivatives of pyrrole, 1,2,3- and 1,2,4- triazoles were synthesized in moderate to good yields in a multigram scale. N-difluoromethyltetrazole was obtained in a low yield.

中文翻译：

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母体唑的二氟甲基化

开发了对母吡咯，1,2,3-三唑，1,2,4-三唑和四唑进行二氟甲基化的方法。吡咯和1,2,3-三唑的二氟甲基化是通过氯二氟甲烷的作用进行的。氯二氟乙酸钠用作1,2,4-三唑和四唑的二氟甲基化剂。吡咯，1,2,3-和1,2,4-三唑的N-二氟甲基衍生物以毫克数规模以中等至良好的产率合成。以低收率获得N-二氟甲基四唑。