The 3D OrbiSIMS—label-free metabolic imaging with subcellular lateral resolution and high mass-resolving power

The 3D OrbiSIMS—label-free metabolic imaging with subcellular lateral resolution and high mass-resolving power, Published online: 13 November 2017; doi:10.1038/nmeth.4504

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The high spatial resolution of secondary ion mass spectrometry and the high resolving power of the Orbitrap mass spectrometer are combined in a single imaging platform, the 3D OrbiSIMS. The instrument's capabilities for resolving lipids and neurotransmitters in the brain with subcellular spatial resolution, and a drug in a single cell in three dimensions is demonstrated.

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中文翻译：

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3D OrbiSIMS —具有亚细胞横向分辨率和高质量分辨能力的无标记代谢成像

3D OrbiSIMS —具有亚细胞横向分辨率和高质量分辨能力的无标记代谢成像

3D OrbiSIMS —具有亚细胞侧向分辨率和高质量分辨能力的无标记代谢成像，在线发布：2017年11月13日；doi：10.1038 / nmeth.4504

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二次离子质谱仪的高空间分辨率和Orbitrap质谱仪的高分辨能力结合在一个成像平台3D OrbiSIMS中。证明了该仪器具有以亚细胞空间分辨率解析大脑中脂质和神经递质的能力，并在三个维度上在单个细胞中解析出了一种药物。

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