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Nonimmune cells equipped with T-cell-receptor-like signaling for cancer cell ablation
Nature Chemical Biology ( IF 12.9 ) Pub Date : , DOI: 10.1038/nchembio.2498 Ryosuke Kojima , Leo Scheller , Martin Fussenegger
Nature Chemical Biology ( IF 12.9 ) Pub Date : , DOI: 10.1038/nchembio.2498 Ryosuke Kojima , Leo Scheller , Martin Fussenegger
Nonimmune cells equipped with T-cell-receptor-like signaling for cancer cell ablation , isJats=true)
中文翻译:
配备T细胞受体样信号传导的非免疫细胞可用于癌细胞消融
配备T细胞受体样信号传导的非免疫细胞可用于癌细胞消融 ,isJats = true)
更新日期:2017-11-13
Nonimmune cells equipped with T-cell-receptor-like signaling for cancer cell ablation, Published online: 13 November 2017; doi:10.1038/nchembio.2498
NatureArticleSnippet(type=short-summary, markup=Engineering of nonimmune cells with a cell-contact sensor and antigen recognition domains enables cell-contact-dependent sensor cell signaling and effector molecule production directed to attack target cells, providing an alternative strategy to chimeric antigen receptor T-cell (CAR-T) technology.
中文翻译:
配备T细胞受体样信号传导的非免疫细胞可用于癌细胞消融
配备T细胞受体样信号传导的非免疫细胞可用于癌细胞消融
配备T细胞受体样信号传导的非免疫细胞用于癌细胞消融,在线发布:2017年11月13日; doi:10.1038 / nchembio.2498
NatureArticleSnippet(type = short-summary,markup =利用细胞接触传感器和抗原识别结构域对非免疫细胞进行工程改造,可以使依赖细胞接触的传感器细胞信号传导和效应分子产生,直接攻击靶细胞,从而为嵌合抗原受体T细胞(CAR-T)技术提供了另一种策略。