Nature Reviews Genetics ( IF 42.7 ) Pub Date : 2017-11-13 , DOI: 10.1038/nrg.2017.86 Andrew E Teschendorff 1, 2, 3 , Caroline L Relton 4
Statistical and integrative system-level analysis of DNA methylation data, Published online: 13 November 2017; doi:10.1038/nrg.2017.86
NatureArticleSnippet(type=short-summary, markup=The wealth of DNA methylation data continues to grow rapidly, including from epigenome-wide association studies (EWAS). However, extracting meaningful biological and clinical information requires diverse computational approaches for data analysis. This Review discusses the range of statistical tools available, including for cell-type deconvolution, identification of important methylation data features, causation and system-level integration with other types of omic data.
中文翻译:
DNA甲基化数据的统计和综合系统级分析
DNA甲基化数据的统计和综合系统级分析
DNA甲基化数据的统计和综合系统级分析,在线发布:2017年11月13日;doi:10.1038/nrg.2017.86
NatureArticleSnippet(类型=简短摘要,标记=DNA 甲基化数据的财富继续快速增长,包括来自表观基因组关联研究 (EWAS) 的数据。然而,提取有意义的生物学和临床信息需要多种计算方法来进行数据分析。本综述讨论了可用的统计工具范围,包括细胞类型去卷积、重要甲基化数据特征的识别、因果关系以及与其他类型组学数据的系统级集成。