Methyl ketone break-and-rebuild: a strategy for full α-heterofunctionalization of acetophenones,Green Chemistry

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Methyl ketone break-and-rebuild: a strategy for full α-heterofunctionalization of acetophenones
Green Chemistry ( IF 9.3 ) Pub Date : 2017-10-17 00:00:00 , DOI: 10.1039/c7gc02558k
Thanh Binh Nguyen _{1,

2,

3,

4,

5} , Pascal Retailleau _{1,

2,

3,

4,

5}

Affiliation

The Willgerodt reaction under iron-catalyzed aerobic conditions was found to be an excellent tool for full α-heterofunctionalization of acetophenones with sulfur and amines. Via this break-and rebuild strategy, a wide range of thioglyoxamides was synthesized in a four-component, highly atom-, step- and redox-economical manner with water as the only by-product.

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