Supramolecular chemotherapy based on host–guest molecular recognition: a novel strategy in the battle against cancer with a bright future,Chemical Society Reviews

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Supramolecular chemotherapy based on host–guest molecular recognition: a novel strategy in the battle against cancer with a bright future
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2017-10-05 00:00:00 , DOI: 10.1039/c6cs00898d
Jiong Zhou _{1,

2,

3,

4,

5} , Guocan Yu _{1,

2,

3,

4,

5} , Feihe Huang _{1,

2,

3,

4,

5}

Affiliation

Chemotherapy is currently one of the most effective ways to treat cancer. However, traditional chemotherapy faces several obstacles to clinical trials, such as poor solubility/stability, non-targeting capability and uncontrollable release of the drugs, greatly limiting their anticancer efficacy and causing severe side effects towards normal tissues. Supramolecular chemotherapy integrating non-covalent interactions and traditional chemotherapy is a highly promising candidate in this regard and can be appropriately used for targeted drug delivery. By taking advantage of supramolecular chemistry, some limitations impeding traditional chemotherapy for clinical applications can be solved effectively. Therefore, we present here a review summarizing the progress of supramolecular chemotherapy in cancer treatment based on host–guest recognition and provide guidance on the design of new targeting supramolecular chemotherapy combining diagnostic and therapeutic functions. Based on a large number of state-of-the-art studies, our review will advance supramolecular chemotherapy on the basis of host–guest recognition and promote translational clinical applications.

中文翻译：

基于宿主-客体分子识别的超分子化学疗法：抗击癌症的新策略，前景光明

化学疗法是目前治疗癌症最有效的方法之一。然而，传统的化学疗法面临临床试验的几个障碍，例如溶解性/稳定性差，非靶向能力和药物的释放不受控制，极大地限制了其抗癌功效并导致对正常组织的严重副作用。结合非共价相互作用和传统化学疗法的超分子化学疗法在这方面是非常有前途的候选方法，可以适当地用于靶向药物递送。通过利用超分子化学的优势，可以有效地解决一些阻碍传统化学疗法用于临床的局限性。所以，我们在此进行综述，概述基于宿主-客体识别的超分子化学疗法在癌症治疗中的进展，并为结合诊断和治疗功能的新型靶向超分子化学疗法的设计提供指导。基于大量的最新研究，我们的综述将在宿主-客体识别的基础上推进超分子化学疗法并促进翻译临床应用。

更新日期：2017-11-13

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