We found for the first time that a thrombin-binding DNA aptamer (TBA) is selectively entrapped in fibrin gels during the gel growth reaction catalyzed by thrombin. Furthermore, using this phenomenon, we successfully demonstrated multiple incorporation of amphiphilic aliphatic groups into fibrin gels via chemically modified TBA.

中文翻译：

---

通过化学修饰的DNA适体选择性地将外来功能结合到纤维蛋白凝胶中

我们首次发现，在凝血酶催化的凝胶生长反应过程中，凝血酶结合DNA适体（TBA）被选择性地包埋在纤维蛋白凝胶中。此外，利用这种现象，我们成功地证明了通过化学修饰的TBA将两亲脂族基团多次掺入纤维蛋白凝胶中。