Abstract A simple method has been developed to synthesize carbon dot capped gold nanoflower (CD/AuNF) nanohybrids. In principle, anodic electrochemiluminescent (ECL) carbon dots (CDs) with a lot of reductive functional groups were used to react with oxidative hydrogen tetrachloroaurate trihydrate in the presence of trisodium citrate. The obtained globular CD/AuNF nanohybrids had uniform sizes of 50–60 nm. The CD/AuNF nanohybrids were composed of gold nanoparticle aggregates in the centers and CDs on the surfaces. The easy self-assembly with some bio-molecules of AuNFs and the unique ECL activities of the CDs, made the obtained CD/AuNF nanohybrids promising in biosensing. For instance, a novel ECL aptasensor for thrombin (TB) detection has been developed based on the CD/AuNF nanohybrids. The aptasensor showed good selectivity towards TB. Furthermore, it presented a wide linear response range from 0.5 nM to 40 nM and a low detection limit (S/N = 3) of 0.08 nM.

中文翻译：

---

用于凝血酶电化学发光适体传感器的碳点覆盖金纳米花

摘要 已开发出一种简单的方法来合成碳点封端的金纳米花 (CD/AuNF) 纳米杂化物。原则上，在柠檬酸三钠存在下，使用具有大量还原性官能团的阳极电化学发光（ECL）碳点（CD）与氧化性四氯金酸氢三水合物反应。获得的球状 CD/AuNF 纳米杂化物具有 50-60 nm 的均匀尺寸。CD/AuNF 纳米杂化物由中心的金纳米颗粒聚集体和表面的 CD 组成。与一些 AuNFs 生物分子的简单自组装和 CDs 独特的 ECL 活性，使获得的 CD/AuNF 纳米杂化物在生物传感中很有前途。例如，基于 CD/AuNF 纳米杂化物开发了一种用于凝血酶 (TB) 检测的新型 ECL 适体传感器。适体传感器对 TB 显示出良好的选择性。