The asymmetric vinylogous Mannich reaction (AVMR) of α,α‐dicyanoalkenes with α‐fluoroalkyl sulfinyl imines has been successfully accomplished. This transformation is unprecedented with fluorinated imines and, at the same time, the use of dicyanoalkenes in AVMR has been scarcely reported. Several fluorinated sulfinyl imines are compatible with the process, which gives access to a family of chiral fluorinated amines with an excellent level of stereocontrol. Interestingly, the selectivity found in our protocol is the opposite of that encountered in analogous, previously reported AVMRs. Additionally, the synthetic applicability of the addition products has been exemplified with several transformations showing the particular reactivity of the dicyanoalkene moiety of these α‐fluorinated amines.

中文翻译：

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α，α-二氰基烯烃向α-氟代烷基亚磺酰基亚胺的不对称Vinnlogous Mannich型加成

已成功完成α，α-二氰基烯烃与α-氟烷基亚磺酰基亚胺的不对称乙烯基曼尼希反应（AVMR）。对于氟化亚胺而言，这种转变是前所未有的，同时，几乎没有报道在AVMR中使用二氰基烯烃。几种氟化亚磺酰基亚胺与该工艺兼容，从而可以获得具有出色立体控制水平的手性氟化胺家族。有趣的是，在我们的方案中发现的选择性与以前报道的类似的AVMR中所遇到的相反。另外，加成产物的合成适用性已通过几次转化得到了例证，这些转化显示了这些α-氟代胺的二氰基烯烃部分的特殊反应性。