Acid/Base‐Co‐catalyzed Direct Oxidative α‐Amination of Cyclic Ketones: Using Molecular Oxygen as the Oxidant,Advanced Synthesis & Catalysis

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Acid/Base‐Co‐catalyzed Direct Oxidative α‐Amination of Cyclic Ketones: Using Molecular Oxygen as the Oxidant
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2017-11-28 , DOI: 10.1002/adsc.201701103
Yi-Jin Li ₁ , Lu Zhang ₁ , Na Yan ₁ , Xiang-He Meng ₁ , Yu-Long Zhao ₁

Affiliation

A novel acid/base‐co‐catalyzed direct intermolecular α‐amination of various cyclic ketones has been developed for the first time. The reaction employs molecular oxygen as the sole oxidant under metal‐free conditions. The reaction tolerates a wide range of various anilines, especially primary diamine derivatives, and provides a simple and efficient method for the constructions of α‐amino enones and benzodiazepine derivatives in a single step.

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