R- and Z-Axis Patterned Scaffolds Mimic Tracheal Circumferential Compliance and Longitudinal Extensibility,ACS Biomaterials Science & Engineering

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R- and Z-Axis Patterned Scaffolds Mimic Tracheal Circumferential Compliance and Longitudinal Extensibility
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2017-11-28 00:00:00 , DOI: 10.1021/acsbiomaterials.7b00641
Elizabeth M. Boazak ₁ , Jamie M. Benson ₁ , Debra T. Auguste ₁

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There remains no routine treatment for congenital tracheal abnormalities affecting more than 1/3 of the length. Natural and artificial prostheses are plagued by mechanical failure and inconsistent outcomes. Mimicking native tissue mechanics in an engineered replacement may improve functional and patient outcomes. We synthesized tubular constructs comprising photo-cross-linked methyl acrylate-co-methyl methacrylate, p(MA-co-MMA), with patterned r- and z-axes in order to achieve mechanical properties similar to lamb tracheae. Hard and soft alternating bands, and a soft vertical section, mimic tracheal architecture. Patterned constructs were capable of 46% elastic longitudinal extension. The construct longitudinal composite modulus, 0.34 ± 0.09 MPa, was not significantly different from ovine tracheae. The superior of two geometries evaluated supports up to a 46% reduction of internal volume within the physiological range of transmural pressures. Thus, these patterned hydrogels yielded longitudinal elasticity and radial rigidity while allowing for radial deformation required for effective coughing.

中文翻译：

R和Z轴图案支架模仿气管周向顺应性和纵向可扩展性

对于先天性气管异常的影响超过长度的1/3，目前尚无常规治疗方法。天然假体和人工假体受到机械故障和结果不一致的困扰。在工程替代中模仿天然组织力学可以改善功能和患者预后。我们合成了包括光交联的丙烯酸甲酯-共-甲基丙烯酸甲酯，P（MA-管状构建体共-MMA），具有图案化- [R -和ž-轴以达到类似于羊气管的机械性能。硬和软交替带，以及柔软的垂直截面，模仿气管结构。图案化的构建体能够进行46％的弹性纵向延伸。构造物的纵向复合模量为0.34±0.09 MPa，与绵羊气管没有显着差异。所评估的两种几何形状的优越性可在透壁压力的生理范围内将内部容积减少多达46％。因此，这些图案化的水凝胶产生了纵向弹性和径向刚度，同时允许有效咳嗽所需的径向变形。

更新日期：2017-11-28

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