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Targeting ncRNAs by plant secondary metabolites: The ncRNAs game in the balance towards malignancy inhibition
Biotechnology Advances ( IF 12.1 ) Pub Date : 2017-11-10 , DOI: 10.1016/j.biotechadv.2017.11.003
Diana Gulei , Nikolay Mehterov , Seyed Mohammad Nabavi , Atanas Georgiev Atanasov , Ioana Berindan-Neagoe

The current trend of combining state of the art technologies with quondam treatments in order to overcome existing gaps in the clinical area determined an increased interest into polyphenols, common dietary phytochemicals, for the prevention and treatment of chronic diseases, especially cancer. The reemergence of polyphenols in the cancer field is sustained by advanced-omics technologies able to identify coding and non-coding genes and their related signaling pathways modulated by natural compounds. Identification of the structural correspondence between interacting molecules will allow the development of more targeted and informed therapeutic strategies for cancer management.



中文翻译:

通过植物次生代谢物靶向ncRNA:ncRNA在平衡恶性肿瘤中发挥作用

为了克服临床领域中现有的差距,将最新技术与昆达姆疗法相结合的当前趋势决定了人们对预防和治疗慢性疾病(尤其是癌症)的多酚,常见的饮食植物化学物质的兴趣日益浓厚。多酚在癌症领域的兴起是通过先进的组学技术得以实现的,该技术能够识别编码和非编码基因以及由天然化合物调节的相关信号传导途径。相互作用分子之间的结构对应的鉴定将允许开发更有针对性和知情的癌症治疗策略。

更新日期:2017-11-10
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