How can we transform an immune desert into a ‘hot tumor’ that is prone to respond to anti-programmed death (PD)-1 immunotherapy? This might be possible by injecting an oncolytic virus, engineered to induce local immune stimulation, prior to anti-PD-1 therapy. A recent study demonstrated that this combination – evaluated in a Phase Ib metastatic melanoma clinical study – yields promising results.

中文翻译：

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Checkpoint封锁​​加溶瘤病毒：一种热门的治疗癌症策略

我们如何将免疫沙漠变成易于对抗程序性死亡（PD）-1免疫疗法作出反应的“热肿瘤”？这可以通过在抗PD-1治疗之前注射经改造以诱导局部免疫刺激的溶瘤病毒来实现。最近的一项研究表明，这种结合-在Ib期转移性黑素瘤临床研究中进行了评估-产生了可喜的结果。