The discovery that the Murphy Roths Large (MRL) mouse strain is a fully competent, epimorphic tissue regenerator, proved that the machinery of regeneration was preserved through evolution from hydra, to salamanders, to mammals. Such concepts have allowed translation of the biology of amphibians, and their ability to regenerate, to a mammalian context. We identified the ancient hypoxia-inducible factor (HIF)-1α pathway, operating through prolyl hydroxylase domain proteins (PHDs), as a central player in mouse regeneration. Thus, the possibility of targeting PHDs or other HIF-1α modifiers to effectively recreate the amphibian regenerative state has emerged. We posit that these regenerative pathways are critical in mammals. Moreover, the current approved use of PHD inhibitors in the clinic should allow fast-track translation from mouse studies to drug-based regenerative therapy in humans.

Murphy Roths Large（MRL）小鼠品系是一种完全有能力的表观组织再生器，这一发现证明了再生机制是通过从水hydr，to到哺乳动物的进化而得以保留的。这些概念使两栖动物的生物学及其再生能力转化为哺乳动物。我们确定了古代的缺氧诱导因子（HIF）-1α途径，通过脯氨酰羟化酶域蛋白（PHDs）运作，是小鼠再生中的重要角色。因此，已经出现了靶向PHD或其他HIF-1α修饰子以有效地重建两栖动物再生状态的可能性。我们认为这些再生途径在哺乳动物中至关重要。而且，